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Analysis of drug resistance in HIV protease

Abstract Background Drug resistance in HIV is the major problem limiting effective antiviral therapy. Computational techniques for predicting drug resistance profiles from genomic data can accelerate the appropriate choice of therapy. These techniques can also be used to select protease mutants for...

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Autors principals: Shrikant D. Pawar, Christopher Freas, Irene T. Weber, Robert W. Harrison
Format: Artigo
Idioma:Inglês
Publicat: BMC 2018-10-01
Col·lecció:BMC Bioinformatics
Matèries:
HIV protease
Drug resistance
Machine learning
RBM
Structure-based
Accés en línia:http://link.springer.com/article/10.1186/s12859-018-2331-y
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