Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

<p><b>Abstract</b></p> <p><b>Background</b></p> <p>WNT-5A signaling in the central nervous system is important for morphogenesis, neurogenesis and establishment of functional connectivity; the source of WNT-5A and its importance for cellular comm...

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Détails bibliographiques
Auteurs principaux: Halleskog Carina, Dijksterhuis Jacomijn, Kilander Michaela Brita, Becerril-Ortega Javier, Villaescusa Juan, Lindgren Eva, Arenas Ernest, Schulte Gunnar
Format: Artigo
Langue:Inglês
Publié: BMC 2012-05-01
Collection:Journal of Neuroinflammation
Sujets:
Frizzled
Heterotrimeric G proteins
MAPK
Non-canonical WNT signaling
Cyclic AMP
Microglia
Neuroinflammation
Accès en ligne:http://www.jneuroinflammation.com/content/9/1/111
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