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Evolution of Conformational Disorder & Diversity of the P53 Interactome

The tumour suppressor p53 is now known to be an ancient transcription factor that had already evolved interaction sites with its partner protein MDM2 at the dawn of multi-cellular eukaryotic animal life. The billion-year life history of the p53-MDM2 axis has permitted significant time for the protei...

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Detalhes bibliográficos
Main Authors: Anne-Sophie Huart, Ted R. Hupp
Formato: Artigo
Idioma:Inglês
Publicado em: Pensoft Publishers 2013-08-01
Colecção:BioDiscovery
Acesso em linha:https://biodiscovery.pensoft.net/article/8952/download/pdf/
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