Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury

Abstract Neuroinflammation is a secondary response following ischemia stroke. Arginine is a non-essential amino acid that has been shown to inhibit acute inflammatory reaction. In this study we show that arginine treatment decreases neuronal death after rat cerebral ischemia/reperfusion (I/R) injury...

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Hauptverfasser: Song-Feng Chen, Meng-Xian Pan, Jun-Chun Tang, Jing Cheng, Dan Zhao, Ya Zhang, Hua-Bao Liao, Rui Liu, Yang Zhuang, Zhi-Feng Zhang, Juan Chen, Rui-Xue Lei, Shi-Fang Li, Huan-Ting Li, Ze-Fen Wang, Qi Wan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2020-04-01
Schriftenreihe:Molecular Brain
Schlagworte:
Arginine
Neuroinflammation
Ischemia stroke
LDHA
HIF-1α
Neuroprotection
Online Zugang:http://link.springer.com/article/10.1186/s13041-020-00601-9
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