ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

Abstract Background Epithelial mesenchymal transition (EMT) is tightly regulated by a network of transcription factors (EMT-TFs). Among them is the nuclear factor ZEB2, a member of the zinc-finger E-box binding homeobox family. ZEB2 nuclear localization has been identified in several cancer types, a...

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Hlavní autoři: Nicolas Skrypek, Kenneth Bruneel, Cindy Vandewalle, Eva De Smedt, Bieke Soen, Nele Loret, Joachim Taminau, Steven Goossens, Niels Vandamme, Geert Berx
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2018-11-01
Edice:Epigenetics & Chromatin
Témata:
EMT
ZEB2
Epigenetic regulation
RAB25
SIRT1
DNMT
On-line přístup:http://link.springer.com/article/10.1186/s13072-018-0239-4
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