WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity

Background: The role of aberrant DNA methylation in allopurinol-induced severe cutaneous adverse reactions (SCARs) is incompletely understood. To fill the gap, we analyze the DNA methylation profiling in allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients...

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Detalhes bibliográficos
Main Authors: Lin Cheng, Bao Sun, Yan Xiong, Lei Hu, Lichen Gao, Ji Li, Hongfu Xie, Xiaoping Chen, Wei Zhang, Hong-Hao Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-03-01
Colecção:Journal of Personalized Medicine
Assuntos:
drug hypersensitivity
epigenetics
DNA methylation
allopurinol-induced severe cutaneous adverse reactions (SCARs)
weighted gene co-expression network analysis (WGCNA)
ATG13
Acesso em linha:https://www.mdpi.com/2075-4426/12/4/525
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