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Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels

Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype a...

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書誌詳細
主要な著者: Fenling Fan, Hua Tian, Jie Geng, Jizhao Deng, Ya Liu, Chunyan Chen, Songlin Zhang, Yushun Zhang, Jie Li, Hongyan Tian, Anthony M. Dart, Yuliang Zou
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2019-01-01
シリーズ:Frontiers in Pharmacology
主題:
オンライン・アクセス:https://www.frontiersin.org/article/10.3389/fphar.2018.01518/full
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