Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production

Transmissible gastroenteritis virus (TGEV), an enteropathogenic coronavirus (CoV) of porcine, causes lethal watery diarrhea and severe dehydration in piglets and leads to severe economic losses in the swine industry. Unlike most CoVs that antagonize type I interferon (IFN) production, previous studi...

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Detalhes bibliográficos
Main Authors: Yanrong Zhou, Wei Wu, Lilan Xie, Dang Wang, Qiyun Ke, Zhenzhen Hou, Xiaoli Wu, Ying Fang, Huanchun Chen, Shaobo Xiao, Liurong Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-08-01
Colecção:Frontiers in Immunology
Assuntos:
transmissible gastroenteritis virus
non-structural protein 14
DDX1
interferon-beta
innate immune response
pattern-recognition receptors
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00940/full
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