EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells

Misexpression of chromatin modification factors and changed epigenetic modifications play crucial roles for tumorigenesis. Our previous studies demonstrated that inhibition of epigenetic modification enzymes EZH2, LSD1, DNMTs, and HDACs caused post-mitotic neuron-like differentiation in different ca...

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Detalhes bibliográficos
Principais autores: Anhua Lei, Lu Chen, Min Zhang, Xiaoli Yang, Liyang Xu, Ning Cao, Zan Zhang, Ying Cao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-05-01
coleção:Frontiers in Genetics
Assuntos:
cancer cell
neural progenitor cell
chromatin modification factors
gene regulation
neuronal differentiation
protein turnover
Acesso em linha:https://www.frontiersin.org/article/10.3389/fgene.2019.00422/full
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