CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

Summary: Non-coding DNA variants (NCVs) impact gene expression by altering binding sites for regulatory complexes. New high-throughput methods are needed to characterize the impact of NCVs on regulatory complexes. We developed CASCADE (Customizable Approach to Survey Complex Assembly at DNA Elements...

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Hauptverfasser: David Bray, Heather Hook, Rose Zhao, Jessica L. Keenan, Ashley Penvose, Yemi Osayame, Nima Mohaghegh, Xiaoting Chen, Sreeja Parameswaran, Leah C. Kottyan, Matthew T. Weirauch, Trevor Siggers
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2022-02-01
Schriftenreihe:Cell Genomics
Schlagworte:
cofactor
transcription factor
recruitment
single-nucleotide polymorphism
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Online Zugang:http://www.sciencedirect.com/science/article/pii/S2666979X22000155
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