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Puerarin suppresses hypoxia-induced vascular endothelial growth factor upregulation in human retinal pigmented epithelial cells by blocking JAK2/STAT3 pathway

The purpose of this study was to explore the mechanism by which puerarin regulated the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in humans’ retinal pigment epithelial (RPE) cells under hypoxia. RPE cells (ARPE-19 and D407 cells) and a rat model...

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Autors principals: Huixin Tang, Lingchun Kong, Yuqin Yang, Jingjing Li, Hong Zou
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2022-05-01
Col·lecció:Bioengineered
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Accés en línia:https://www.tandfonline.com/doi/10.1080/21655979.2022.2070586
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