A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population

Abstract Objective The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S-methyltransferase (TPMT) activity, contribute...

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Main Authors: Kok-Siong Poon, Izz Irfan B. Imran, Silvester Kheng-Han Chew, Patrice Tan, Karen Mei-Ling Tan
格式: Artigo
語言:Inglês
出版: BMC 2022-04-01
叢編:BMC Research Notes
主題:
NUDT15
Thiopurine
Pharmacogenetics
Direct sequencing
在線閱讀:https://doi.org/10.1186/s13104-021-05821-3
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