Copy number and loss of heterozygosity detected by SNP array of formalin-fixed tissues using whole-genome amplification.

The requirement for large amounts of good quality DNA for whole-genome applications prohibits their use for small, laser capture micro-dissected (LCM), and/or rare clinical samples, which are also often formalin-fixed and paraffin-embedded (FFPE). Whole-genome amplification of DNA from these samples...

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Main Authors: Angela Stokes, Ignat Drozdov, Eliete Guerra, Christos A Ouzounis, Saman Warnakulasuriya, Michael J Gleeson, Mark McGurk, Mahvash Tavassoli, Edward W Odell
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3180289?pdf=render
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