Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion

Background. Reactive oxygen species- (ROS-) mediated ischemia-reperfusion injury (IRI) detrimentally impacts liver transplantation and resection. 12/15-Lipoxygenase (12/15-LOX), an antagonistic protein of the glutathione peroxidase 4 (GPX4) signaling cascade, was proven to mediate cell death in post...

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Main Authors: Moritz Drefs, Michael N. Thomas, Markus Guba, Martin K. Angele, Jens Werner, Marcus Conrad, Christian J. Steib, Lesca M. Holdt, Joachim Andrassy, Andrej Khandoga, Markus Rentsch
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2017-01-01
Colecção:Oxidative Medicine and Cellular Longevity
Acesso em linha:http://dx.doi.org/10.1155/2017/8325754
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