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Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and crea...

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Detalhes bibliográficos
Main Authors: Schneider, Manuela, Wortmann, Markus, Mandal, Pankaj Kumar, Arpornchayanon, Warangkana, Jannasch, Katharina, Alves, Frauke, Strieth, Sebastian, Conrad, Marcus, Beck, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838443/
https://ncbi.nlm.nih.gov/pubmed/20234819
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