Genotype Phenotype Correlation of Genetic Polymorphism of PPAR Gamma Gene and Therapeutic Response to Pioglitazone in Type 2 Diabetes Mellitus-A Pilot Study

Introduction: Pro12Ala polymorphism is a missense mutation at codon 12 in peroxisome proliferator-activated receptor γ gene (PPARG). This polymorphism is known to be associated with increased insulin sensitivity. Pioglitazone, a thiazolidinedione, is an anti-diabetic drug which acts as an agonis...

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Hlavní autoři: S. Shanmuga Priya, Ramalingam Sankaran, Sudha Ramalingam, Thiagarajan Sairam, LS Somasundaram
Médium: Artigo
Jazyk:Inglês
Vydáno: JCDR Research and Publications Private Limited 2016-02-01
Edice:Journal of Clinical and Diagnostic Research
Témata:
pioglitazone
pro12ala
pharmacogenetic
glycaemic response
south india
On-line přístup:https://jcdr.net/articles/PDF/7331/16494_CE[Ra1]_F(AK)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf
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