Synthesis and Biological Evaluation of New Pyridothienopyrimidine Derivatives as Antibacterial Agents and <i>Escherichia coli</i> Topoisomerase II Inhibitors

The growing resistance of bacteria to many antibiotics that have been in use for several decades has generated the need to discover new antibacterial agents with structural features qualifying them to overcome the resistance mechanisms. Thus, novel pyridothienopyrimidine derivatives (<b>2a<...

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Egile Nagusiak: Eman M. Mohi El-Deen, Eman A. A. Abd El-Meguid, Eman A. A. Karam, Eman S. S. Nossier, Marwa F. F. Ahmed
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI AG 2020-10-01
Saila:Antibiotics
Gaiak:
pyridothienopyrimidines
antibacterial activity
enzyme inhibition
DNA gyrase
topoisomerase IV
molecular docking
Sarrera elektronikoa:https://www.mdpi.com/2079-6382/9/10/695
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