A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation

Abstract Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the homodimerization contributes hug...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Jin Yan, Xiaoqiang Zheng, Weiming You, Wangxiao He, Guang‐Kui Xu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2022-04-01
Seri Bilgileri:Advanced Science
Konular:
bionic‐dimerization
nanomedicine
peptide
protein–protein interactions
statistical mechanics theory
Online Erişim:https://doi.org/10.1002/advs.202105179
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller