A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation

Abstract Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the homodimerization contributes hug...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Jin Yan, Xiaoqiang Zheng, Weiming You, Wangxiao He, Guang‐Kui Xu
التنسيق: Artigo
اللغة:Inglês
منشور في: Wiley 2022-04-01
سلاسل:Advanced Science
الموضوعات:
bionic‐dimerization
nanomedicine
peptide
protein–protein interactions
statistical mechanics theory
الوصول للمادة أونلاين:https://doi.org/10.1002/advs.202105179
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