Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses

The extracellular domain of influenza M2 protein (M2e) is highly conserved and is a promising target for development of universal influenza vaccines. Here, we synthesized a peptide vaccine consisting of M2e epitope linked to a fibrillizing peptide, which could self-assemble into nanoparticle in phys...

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Detalhes bibliográficos
Main Authors: Qimin Wang, Yuling Zhang, Peng Zou, Meixiang Wang, Weihui Fu, Jialei She, Zhigang Song, Jianqing Xu, Jinghe Huang, Fan Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Microbiology
Assuntos:
influenza
M2e
peptide
self-assembly
nanoparticle
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2020.01961/full
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