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Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma.

Alzheimer's disease (AD) is a neurodegenerative disorder associated with increased oxidative stress and neuroinflammation. Markers of increased protein, lipid and nucleic acid oxidation and reduced activities of antioxidant enzymes have been reported in AD plasma. Amyloid plaques in the AD brai...

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Detalhes bibliográficos
Main Authors: Tharusha Jayasena, Anne Poljak, Nady Braidy, George Smythe, Mark Raftery, Mark Hill, Henry Brodaty, Julian Trollor, Nicole Kochan, Perminder Sachdev
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4364672?pdf=render
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