Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates.

Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that utilizes inhalation of small-particle virus aerosols to define mecha...

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Hauptverfasser: Jacqueline Corry, Gwenddolen Kettenburg, Amit A Upadhyay, Megan Wallace, Michelle M Marti, Elizabeth R Wonderlich, Stephanie J Bissel, Kyndal Goss, Timothy J Sturgeon, Simon C Watkins, Douglas S Reed, Steven E Bosinger, Simon M Barratt-Boyes
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2022-03-01
Schriftenreihe:PLoS Pathogens
Online Zugang:https://doi.org/10.1371/journal.ppat.1010395
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