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Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.

Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the actio...

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Detalhes bibliográficos
Main Authors: Ling Yi, Yanlin Zhao, Xiaojue Wang, Min Dai, Karl Erik Hellström, Ingegerd Hellström, Hongtao Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3897701?pdf=render
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