Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

ABSTRACT Most of SARS-CoV-2 neutralizing antibodies (nAbs) targeted the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein. However, mutations at RBD sequences found in the emerging SARS-CoV-2 variants greatly reduced the effectiveness of nAbs. Here we showed that four nAbs, S2-4D, S2...

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Main Authors: Chia-Jung Li, Tai-Ling Chao, Ting-Yu Chang, Chia-Chun Hsiao, De-Chao Lu, Yi-Wei Chiang, Guan-Chun Lai, Ya-Min Tsai, Jun-Tung Fang, Siman Ieong, Jann-Tay Wang, Sui-Yuan Chang, Shih-Chung Chang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2022-04-01
Colecção:Microbiology Spectrum
Assuntos:
neutralizing antibodies
SARS-CoV-2
spike (S) protein
S2 subunit
membrane fusion
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.01814-21
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