Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear. This is exemplified by a set of iconic and well-characterized monoclonal antibodies developed after the 2003 SARS outbreak, in...

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Detalhes bibliográficos
Main Authors: Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson, Daniel Christ
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2021-01-01
Colecção:mAbs
Assuntos:
Monoclonal antibodies
antibody maturation
antibody engineering
phage display
SARS-CoV-2
structural studies
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2021.1922134
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