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p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression
Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated. This study revealed that I3M promotes the expression of death receptor 5 (DR5) and tumor necrosis factor (TNF)-related apoptosis-ind...
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Main Authors: | , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
MDPI AG
2019-09-01
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叢編: | Antioxidants |
主題: | |
在線閱讀: | https://www.mdpi.com/2076-3921/8/10/423 |
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