p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression

Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated. This study revealed that I3M promotes the expression of death receptor 5 (DR5) and tumor necrosis factor (TNF)-related apoptosis-ind...

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Hlavní autoři: Matharage Gayani Dilshara, Ilandarage Menu Neelaka Molagoda, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Yung Hyun Choi, Cheol Park, Kyoung Tae Lee, Seungheon Lee, Gi-Young Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2019-09-01
Edice:Antioxidants
Témata:
indirubin-3′-monoxime
p53
death receptor 5
TNF-related apoptosis-inducing ligand
transcription factor C/EBP homologous protein
On-line přístup:https://www.mdpi.com/2076-3921/8/10/423
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