T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Abstract Background A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c+ B cells in the development of lupus is unclear. Ch...

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Detalhes bibliográficos
Main Authors: Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B. Harley, Yuanjia Tang, Nan Shen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-10-01
Colecção:Arthritis Research & Therapy
Assuntos:
Systemic lupus erythematosus
Chronic graft-versus-host disease
B cell
Antichromatin antibody
T-bet
Acesso em linha:http://link.springer.com/article/10.1186/s13075-017-1438-2
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