Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder

Background: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as docume...

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Main Authors: Keren Bachi, Muhammad A. Parvaz, Scott J. Moeller, Gabriela Gan, Anna Zilverstand, Rita Z. Goldstein, Nelly Alia-Klein
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-02-01
Colecção:Frontiers in Human Neuroscience
Assuntos:
cocaine dependence
childhood maltreatment
gray matter
voxel-based morphometry
addiction
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fnhum.2018.00051/full
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