Pretreatment of Sialic Acid Efficiently Prevents Lipopolysaccharide-Induced Acute Renal Failure and Suppresses TLR4/gp91-Mediated Apoptotic Signaling

Background/Aims: Lipopolysaccharides (LPS) binding to Toll-like receptor 4 (TLR4) activate NADPH oxidase gp91 subunit-mediated inflammation and oxidative damage. Recognizing the high binding affinity of sialic acid (SA) with LPS, we further explored the preventive potential of SA pretreatment on LPS...

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Main Authors: Shih-Ping Hsu, Chin-Chih Chen, Chiang-Ting Chien
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2016-05-01
Colecção:Kidney & Blood Pressure Research
Assuntos:
Lipopolysaccharide
Sialic acid
Reactive oxygen species
Apoptosis
Gp91
Toll-like receptors
Acesso em linha:http://www.karger.com/Article/FullText/443430
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