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Inference of gene regulatory networks with sparse structural equation models exploiting genetic perturbations.

Integrating genetic perturbations with gene expression data not only improves accuracy of regulatory network topology inference, but also enables learning of causal regulatory relations between genes. Although a number of methods have been developed to integrate both types of data, the desiderata of...

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Bibliografiske detaljer
Main Authors: Xiaodong Cai, Juan Andrés Bazerque, Georgios B Giannakis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-01-01
Serier:PLoS Computational Biology
Online adgang:http://europepmc.org/articles/PMC3662697?pdf=render
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