Engineering chimeric antigen receptor-T cells for cancer treatment

Abstract Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell therapy has been successfully applied in the treatment of B-cell malignancies, un...

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Detalhes bibliográficos
Main Authors: Baixin Ye, Creed M. Stary, Xuejun Li, Qingping Gao, Chunsheng Kang, Xiaoxing Xiong
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-02-01
Colecção:Molecular Cancer
Assuntos:
Tumor ecosystem
Intratumor heterogeneity
T-cell exhaustion
Cancer immunotherapy
Chimeric antigen receptor (CAR) T cell therapy
Acesso em linha:http://link.springer.com/article/10.1186/s12943-018-0814-0
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