Systematic evaluation of C. elegans lincRNAs with CRISPR knockout mutants

Abstract Background Long intergenic RNAs (lincRNAs) play critical roles in eukaryotic cells, but systematic analyses of the lincRNAs of an animal for phenotypes are lacking. We generate CRISPR knockout strains for Caenorhabditis elegans lincRNAs and evaluate their phenotypes. Results C. elegans linc...

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Main Authors: Shuai Wei, He Chen, Emmanuel Enoch Dzakah, Bin Yu, Xiaolin Wang, Tao Fu, Jingxin Li, Lei Liu, Shucheng Fang, Weihong Liu, Ge Shan
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2019-01-01
Sraith:Genome Biology
Ábhair:
C. elegans
lincRNA
MicroRNA
CRISPR
Phenotype
Transcription factor
Rochtain Ar Líne:http://link.springer.com/article/10.1186/s13059-018-1619-6
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