Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer

L-arginine (L-Arg) depletion induced by randomly PEGylated arginine deiminase (ADI-PEG20) can treat arginosuccinate synthase (ASS)-negative cancers, and ADI-PEG20 is undergoing phase III clinical trials. Unfortunately, ASS-positive cancers are resistant to ADI-PEG20. Moreover, the yield of ADI produ...

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Main Authors: Sai-Fung Chung, Chi-Fai Kim, Sui-Yi Kwok, Suet-Ying Tam, Yu Wai Chen, Hiu-Chi Chong, Siu-Lun Leung, Pui-Kin So, Kwok-Yin Wong, Yun-Chung Leung, Wai-Hung Lo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-06-01
Colecção:International Journal of Molecular Sciences
Assuntos:
L-Arg
mono-PEGylation
thermostable enzyme
Acesso em linha:https://www.mdpi.com/1422-0067/21/12/4234
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