Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Abstract Background Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic pro...

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Main Authors: Eilis Hannon, Diana Schendel, Christine Ladd-Acosta, Jakob Grove, iPSYCH-Broad ASD Group, Christine Søholm Hansen, Shan V. Andrews, David Michael Hougaard, Michaeline Bresnahan, Ole Mors, Mads Vilhelm Hollegaard, Marie Bækvad-Hansen, Mady Hornig, Preben Bo Mortensen, Anders D. Børglum, Thomas Werge, Marianne Giørtz Pedersen, Merete Nordentoft, Joseph Buxbaum, M. Daniele Fallin, Jonas Bybjerg-Grauholm, Abraham Reichenberg, Jonathan Mill
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-03-01
Colecção:Genome Medicine
Assuntos:
Autism
DNA methylation
Genetics
Neonatal
Genome-wide association study (GWAS)
Epigenome-wide association study (EWAS)
Acesso em linha:http://link.springer.com/article/10.1186/s13073-018-0527-4
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