Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma

Tumor suppression by the extracts of Azadirachta indica (neem) works via anti-proliferation, cell cycle arrest, and apoptosis, demonstrated previously using cancer cell lines and live animal models. However, very little is known about the molecular targets and pathways that neem extracts and their a...

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Hlavní autoři: Neeraja M. Krishnan, Hiroto Katoh, Vinayak Palve, Manisha Pareek, Reiko Sato, Shumpei Ishikawa, Binay Panda
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2019-03-01
Edice:PeerJ
Témata:
Drug target
Pooled shRNA screen
Neem
Gene expression
HSF-1
TGF-β
On-line přístup:https://peerj.com/articles/6464.pdf
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