Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

Abstract Background Despite recent advances in radiotherapy, radioresistance in patients with pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells (CSCs) represent a major factor in radioresistance. Developing a potent radiosensitizer may be a novel candidate for the...

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Main Authors: Mohammed Salah, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Hiroki Kawaguchi, Tomomi Sogawa, Naritoshi Mukumoto, Chiaki Ogino, Ryohei Sasaki
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Radioresistance
Pancreatic cancer stem cells
Titanium peroxide nanoparticles
Radiosensitizers
Reactive oxygen species
AKT
Acesso em linha:https://doi.org/10.1186/s13046-022-02358-6
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