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Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs: a simulation study.

Cardiomyocytes located at the ischemic border zone of infarcted ventricle are accompanied by redistribution of gap junctions, which mediate electrical transmission between cardiomyocytes. This ischemic border zone provides an arrhythmogenic substrate. It was also shown that sodium (Na+) channels are...

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Bibliografske podrobnosti
Main Authors: Kunichika Tsumoto, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2014-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC4184874?pdf=render
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