The Cancer Aneuploidy Paradox: In the Light of Evolution

Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform the segregation of two pare...

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Detaylı Bibliyografya
Asıl Yazarlar: Kristine Salmina, Anda Huna, Martins Kalejs, Dace Pjanova, Harry Scherthan, Mark S. Cragg, Jekaterina Erenpreisa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2019-01-01
Seri Bilgileri:Genes
Konular:
cancer
aneuploidy
meio-mitosis
disabled spindle
autokaryogamy
somatic pairing
recombination on kinetochores
reduction
chromothripsis
cleavage embryo
Online Erişim:https://www.mdpi.com/2073-4425/10/2/83
Etiketler: Etiketle
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