The Cancer Aneuploidy Paradox: In the Light of Evolution

Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform the segregation of two pare...

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Hlavní autoři: Kristine Salmina, Anda Huna, Martins Kalejs, Dace Pjanova, Harry Scherthan, Mark S. Cragg, Jekaterina Erenpreisa
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2019-01-01
Edice:Genes
Témata:
cancer
aneuploidy
meio-mitosis
disabled spindle
autokaryogamy
somatic pairing
recombination on kinetochores
reduction
chromothripsis
cleavage embryo
On-line přístup:https://www.mdpi.com/2073-4425/10/2/83
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