Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons

<p>Abstract</p> <p>Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and the ligan...

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Bibliografiska uppgifter
Huvudupphovsmän: Langeslag Michiel, Constantin Cristina E, Andratsch Manfred, Quarta Serena, Mair Norbert, Kress Michaela
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publishing 2011-12-01
Serie:Molecular Pain
Ämnen:
inflammation
inflammatory pain
proinflammatory cytokines
heat hypersensitivity
transsignaling
Länkar:http://www.molecularpain.com/content/7/1/102
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