The SAMHD1 rs6029941 (A/G) Polymorphism Seems to Influence the HTLV-1 Proviral Load and IFN-Alpha Levels

SAMHD1, a host dNTPase, acts as a retroviral restriction factor by degrading the pool of nucleotides available for the initial reverse transcription of retroviruses, including HTLV-1. Polymorphisms in the SAMDH1 gene may alter the enzymatic expression and influence the course of infection by the vir...

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Bibliographische Detailangaben
Hauptverfasser: Maria Alice Freitas Queiroz, Ednelza da Silva Graça Amoras, Tuane Carolina Ferreira Moura, Carlos Araújo da Costa, Maisa Silva de Sousa, Sandra Souza Lima, Ricardo Ishak, Antonio Carlos Rosário Vallinoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-05-01
Schriftenreihe:Frontiers in Cellular and Infection Microbiology
Schlagworte:
HTLV-1
SAMHD1
polymorphism
IFN-α
symptomatic
Online Zugang:https://www.frontiersin.org/article/10.3389/fcimb.2020.00246/full
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