Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations

Atrial dilation and atrial fibrillation (AF) are common in Hypertrophic CardioMyopathy (HCM) patients and associated with a worsening of prognosis. The pathogenesis of atrial myopathy in HCM remains poorly investigated and no specific association with genotype has been identified. By re-analysis of...

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Main Authors: Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi, Cecilia Ferrantini
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
hypertrophic cardiomyopathy
atrial myopathy
atrial fibrillation
sarcomere mechanics
sarcomere energetics
excitation-contraction coupling
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.864547/full
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