Ginsenoside Rh2 pretreatment and withdrawal reactivated the pentose phosphate pathway to ameliorate intracellular redox disturbance and promoted intratumoral penetration of adriamycin

Improving the limited penetration, accumulation and therapeutic effects of antitumor drugs in the avascular region of the tumor mass is crucial during chemotherapy. P-gp inhibitors have achieved little success despite significant efforts. Excessive P-gp inhibition disturbed the kinetic balance betwe...

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Hauptverfasser: Jiali Liu, Qingyun Cai, Wenjie Wang, Meng Lu, Jianming Liu, Fang Zhou, Minjie Sun, Guangji Wang, Jingwei Zhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020-05-01
Schriftenreihe:Redox Biology
Schlagworte:
Pentose phosphate pathway reactivation
Intracellular redox status
Intratumoral penetration
Mathematical modeling
“Ginsenoside Rh2-adriamycin” sequential treatment
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2213231719310535
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