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The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice
Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of melatonergic MT 1 and MT 2 receptors and as an antagonist of 5-HT 2C receptors. The present study was undertaken to investigate whether chronic treatment with agomelatine would block unpredictable chronic m...
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Main Authors: | , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
AboutScience Srl
2014-01-01
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Serier: | Drug Target Insights |
Online adgang: | https://doi.org/10.4137/DTI.S13870 |
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