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A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

Summary: Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear....

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Main Authors: Sung-Kyun Park, Xiaorong Zhou, Kathryn E. Pendleton, Olga V. Hunter, Jennifer J. Kohler, Kathryn A. O’Donnell, Nicholas K. Conrad
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017-08-01
Serija:Cell Reports
Online dostop:http://www.sciencedirect.com/science/article/pii/S2211124717309701
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