Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3. PV patient lesions are characterized by flaccid blisters and ultrastructurally by defined hallmarks including a reduction in...

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Hlavní autoři: Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-05-01
Edice:Frontiers in Immunology
Témata:
pemphigus
signaling
desmosomes
ultrastructure
ex vivo skin model
electron microscope
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884067/full
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