Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a “Naive-Memory” Phenotype

Summary: Primary stimulation of T cells is believed to trigger unidirectional differentiation from naive to effector and memory subsets. Here we demonstrate that IL-7 can drive the phenotypic reversion of recently differentiated human central and effector memory CD8+ T cells into a naive-like phenot...

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Hauptverfasser: Guido Frumento, Kriti Verma, Wayne Croft, Andrea White, Jianmin Zuo, Zsuzsanna Nagy, Stephen Kissane, Graham Anderson, Paul Moss, Frederick E. Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020-04-01
Schriftenreihe:iScience
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2589004220301735
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