Candidate Tumor-Suppressor Gene DLEC1 Is Frequently Downregulated by Promoter Hypermethylation and Histone Hypoacetylation in Human Epithelial Ovarian Cancer

Suppression of ovarian tumor growth by chromosome 3p was demonstrated in a previous study. Deleted in Lung and Esophageal Cancer 1 (DLEC1) on 3p22.3 is a candidate tumor suppressor in lung, esophageal, and renal cancers. The potential involvement of DLEC1 in epithelial ovarian cancer remains unknown...

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Main Authors: Joseph Kwong, Ji-Young Lee, Kwong-Kwok Wong, Xiaofeng Zhou, David T.W. Wong, Kwok-Wai Lo, William R. Welch, Ross S. Berkowitz, Samuel C. Mok
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2006-04-01
Colecção:Neoplasia: An International Journal for Oncology Research
Assuntos:
DLEC1
chromosome 3p22.3
promoter hypermethylation
histone hypoacetylation
epithelial ovarian cancer
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558606800667
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