The role of host eIF2α in viral infection

Abstract Background eIF2α is a regulatory node that controls protein synthesis initiation by its phosphorylation or dephosphorylation. General control nonderepressible-2 (GCN2), protein kinase R-like endoplasmic reticulum kinase (PERK), double-stranded RNA (dsRNA)-dependent protein kinase (PKR) and...

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Main Authors: Yuanzhi Liu, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Shaqiu Zhang, Xin-Xin Zhao, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Yin Wang, Zhiwen Xu, Zhengli Chen, Ling Zhu, Qihui Luo, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Xiaoyue Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
Colecção:Virology Journal
Assuntos:
Virus
eIF2α
General translation inhibition
Stress granule
Cell replication cycle
Autophagy/apoptosis
Acesso em linha:http://link.springer.com/article/10.1186/s12985-020-01362-6
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